DNAse and N-acetylcysteine work best when inhaled.
Extra info: These enzymes should be inhaled for best exposure at their site of action. If given orally, these agents would be degraded in the GI tract.
Mucolytic agents decrease mucus production.
Extra info: These agents break down the disulfide bonds, making the mucus more viscous. This action does not decrease the amount of mucus produced.
Mucolytic agents improve mucociliary clearance.
Extra info: By making the mucus more viscous, the host's mucociliary process is more efficient at clearing the mucus.