Anticholinergic effect in the lung
Anticholinergic effects in the lung
Vagal stimulation of the respiratory tract's muscarinic-3 receptors causes airway constriction. By blocking this parasympathetic stimulation, the anticholinergic agents reduce ASM tone and lead to dilatation of the constricted airway.
There are three principle muscarinic (M) receptors: M1=postganglionic and CNS, M2=postsynaptic in heart
The anticholinergic agents are the inhaled bronchodilators of first choice in asthma.
Extra info: The anticholinergic agents are primarily utilized as additional therapy after inhaled steroids and/or β-agonists have been applied. Anticholinergics are often used as first line agents in COPD.
Anticholinergic agents are airway specific.
Extra info: When administered by the inhaled route, anticholinergic remain primarily in the lung. However, systemic administration will affect all cholinergic receptors throughout the body and thus have multiple adverse effects.