Benigne erostate hyperplasia
Hyperplasia of the prostate gland is a common phenomenon in elderly men. Prostate hyperplasia is a benign proliferative disorder which causes continence problems such as hesitancy, intermittent voiding, a diminished stream, incomplete emptying, and postvoid leakage, and repeated urinary tract infections. When the prostate becomes so large that the urethra is blocked completely, urine retention will occur.
Pharmacological treatment of prostate hyperplasia is aimed at diminishing the size of the prostate and/or decrease sphincter tone with α1-antagonists. Indications for surgery are urine retention, repeated infections and a lack of response after drug treatment. Large prostates are not automatically surgically removed and small prostates sometimes need surgery.
Prostate hyperplasia causes difficulties with urination, such as
Extra info: Since the outflow of the urine is blocked (retention), emptying is often not complete, leading to frequency and urgency symptoms.
I Muscarinic receptor antagonists can directly increase urine retention in case of prostate hyperplasia. II Calcium antagonists relieve urinary problems in case of prostate hyperplasia.
Extra info: Although muscarinic antagonists will not cause a direct worsening of the outflow obstruction, they will decrease detrusor activity and worsen the symptoms of incontinence. Calcium antagonists are not used in the treatment of prostate hyperplasia, but α1-antagonists are.