Metyrapone
Metyrapone
Metyrapone is a specific inhibitor of the enzyme 11β-hydroxylase, which is responsible for the conversion of 11-deoxycortisol into cortisol in the adrenal gland. Prior to surgery, metyrapone can be applied as an inhibitor of cortisol synthesis in the treatment of Cushing's disease or of Cushing's syndrome.
The ultimate cure of Cushing’s disease is by surgery.
Extra info: The primary cause of ACTH or cortisol overproduction needs to be surgically removed.