Metyrapone
Metyrapone
Metyrapone is a specific inhibitor of the enzyme 11β-hydroxylase, which is responsible for the conversion of 11-deoxycortisol into cortisol in the adrenal gland. Prior to surgery, metyrapone can be applied as an inhibitor of cortisol synthesis in the treatment of Cushing's disease or of Cushing's syndrome.
1
The ultimate cure of Cushing’s disease is by surgery.
Extra info: The primary cause of ACTH or cortisol overproduction needs to be surgically removed.
