Alkylating agents for SLE
Cyclophosphamide, given intravenously, is often used in acute flare-ups during the advanced stages of SLE when kidneys, heart, and lungs are affected. The drug inhibits the activation and division of inflammatory cells, especially B and T cells. By alkylating DNA, cyclophosphamide inhibits DNA synthesis and cell division.
See also alkylating cytostatics in the oncology chapter.
What is NOT true about SLE?
Extra info: Cyclophosphamide is known to cause bladder toxicity