Delayed response & recurrence
Delayed response and recurrence
This graph shows the typical time course in patients with depression. One of the critiques of the monoamine hypothesis of depression is the fact that there is a significant delay in relief of depressive symptoms (most respond after a few weeks). This is in contrast to the relative quick effect the drugs have on their targets (effects seen within hours). In addition, some patients may suffer from a relapse despite taking antidepressant
Response, resistance, relapse, recurrence, and recovery are the 5 R's of depression.
Extra info: Resistance isn't part of the depressive cycle, but remission is.