Antigen trigger on mast cell

Antigen trigger on mast cell

The membrane of mast cells has Fc receptors for IgE molecules. The IgE molecules attach to the mast cell when bound to an antigen. The IgE-Fc receptor binding triggers:

1) the degranulation process (releasing histamine, proteases, TNF and interleukins)

2) the increased synthesis of interleukins

3) the release of leukotrienes as well as prostaglandins.

1

An allergen directly stimulates the mast cell.

2

Chronic exposure to an antigen will lead to a greater build-up of interleukins in the granules.