Folate synthesis

Folate synthesis

Pteridine and p-amino benzoic acid are the basis of the folic acid synthesis. Folinic acid is synthesized via three enzymes.

Folinic acid itself is required for the formation of purines and pyrimidines for DNA synthesis. In contrast to humans, bacteria must synthesize all their own folinic acid.


Humans obtain folic acid from both their diet and internal synthesis. 


The final product in the folate synthesis pathway is folinic acid.


The chemical structures of PABA and sulfonamides are very similar.