Dopamine neurons (DA)
The source nuclei for dopaminergic neurons are located in the brain stem.
Extra info: The source nuclei come from different areas including the substantia nigra, ventrale tegmentum and hypothalamus.
COMT is the primary mechanism for clearing dopamine from the synapse.
Extra info: The primary mechanism for clearing dopamine from the synapse is reuptake.
There is no negative feedback loop for dopamine.
Extra info: There are two negative feedback loops: one at the axon terminus and the other at the somatodentric end.
5-HT2A receptors play an important role in the modulation of pre-synaptic dopamine release throughout the dopaminergic system.
Extra info: Modulation by presynaptic 5-HT2A receptors is thought to occur only in the mesocortical and nigrastriatal tracts.