last updated 23-05-2024

Histamine neurons

Histamine neurons in the brain

Histamine-releasing neurons are located exclusively in the tubero-mammillary nucleus of the posterior hypothalamus. From there they project to practically all brain regions, with ventral areas (hypothalamus, basal forebrain, amygdala) receiving a particularly strong innervation.


The ventral ascending pathway remains on the ventral surface of the brain, providing innervation mainly to the hypothalamus whilst the dorsal pathway leaves the nucleus dorsally, following the lateral side of the third ventricle to innervate the thalamus, hippocampus, amygdala and rostral forebrain structures.