Acute dystonia is an extrapyramidal movement disorder which can be caused by the administration of antipsychotics. These drugs will block dopaminergic neurotransmission in the nigrostriatal tract and cause an imbalance in the relative dopaminergic versus cholinergic neurotransmission. The resulting
Acute dystonias arise from which physiological situation in the nigrostriatal tract?
Extra info: Although the pathophysiology is thought to be due to an imbalance between DA and ACH, the precipitating factor is a drop in DA neurotransmission.
Extra info: The only risk factor that this patient is missing is a previous history of dystonia.