A tumor (2) of the zona glomerulosa can be the cause of hyperaldosteronism. Rarely, an overactivated angiotensin receptor (1) can result in primary hyperaldosteronism. Secondary hyperaldosteronism is due to increased levels of angiotensin II or renin (3), which cause increased aldosterone secretion (like in liver cirrhosis
I. Adrenalectomy of an aldosterone-producing adrenal tumor is effective in treating aldosterone-induced hypertension. II. Primary hyperaldosteronism is a relatively uncommon cause of hypertension.