This figure shows in greater detail the many factors influencing parietal cell gastric acid secretion. All affected receptors are of the G protein-coupled type and include H2 = histamine 2, G = gastrin, and M3= muscarinic 3, which stimulate secretion. EP = prostanoid E, inhibits parietal cell gastric acid secretion.
The enterochromaffin-like (ECL) cell (not depicted here, but also present in the stomach wall) secretes histamine which in turn affects the parietal cell. Gastrin is produced in the G cell and released into the systemic circulation. When there are high levels of gastric acid in the gastric lumen, the release of gastrin from the G cells is inhibited.
Gastric acid secretion is stimulated by:
Extra info: Although gastrin and histamine stimulate gastric acid secretion, prostaglandins do not.