Due to the selective D2 antagonism in the mesolimbic system, atypical antipsychotics are also useful in bipolar disorders.
Extra info: The pathophysiology of bipolar disorder is largely in the limbic areas. Therefore D2 selectivity in this region is desirable.
Selectivity of risperidone for the 5-HT2A receptor over the D2 receptor seems to be dose dependent.
Extra info: Risperidone is also an atypical antipsychotic like clozapine. However, it seems to lose its preference for the 5HT2A receptor with increasing doses, therefore producing extrapyramidal side effects.
Atypical antipsychotics are more effective in treating psychosis than that of the low or high potency antipsychotics.
Extra info: To date, no large study has found one antipsychotic agent to be better than another when it comes to treating psychotic symptoms. Many claims have been made regarding better tolerability (i.e. less side effects, fewer doses, etc.)