GRs translational responses
Ligand directed signalling
Dissociated compounds.This name refers to a class of molecules that distinguish between different mechanisms of action of the receptor - they cannot be classified as classical agonists or antagonist of a receptor itself, but as having agonistic effects on some of the effector mechanisms. An example is dissociation between anti-inflammatory and metabolic effects.
The transactivation mechanism by direct DNA binding of GR is responsible for many metabolic effects. The transrepression of pro-inflammatory genes via interference with other transcription factors accounts for many anti-inflammatory effects of GCs. Novel compounds may dissociate between these two mechanisms and achieve anti-inflammatory effects in absence of metabolic side effects.