In this graphic are pictured the parts of a bacteria that are susceptible to antibiotics. Bacteria are prokaryotic cells. Antimicrobial drugs are targeted against the cell wall, folic acid synthesis, bacterial genetic material, RNA synthesis, or bacterial protein synthesis.
Antibiotics must cross the bacterial nuclear membrane to interfere with DNA.
Extra info: Bacteria are prokaryotic cells and thus do not contain a nuclear membrane to cross.
Bacteria have a cell wall.
The site of infection is the most important host factor when determining the dose of drugs.
Extra info: It is essential that the drug reaches the site of infection at a concentration above the minimum inhibitory concentration and/or above the minimum bactericidal concentration in case of infection such as meningitis, endocarditis and osteomyelitis.