Glucocorticoids (or corticosteroids) are the most potent anti-inflammatory drugs and they have several modes of action. These include local anti-inflammatory effects that result from the inhibition of mediators of the arachidonic acid pathway in cells and by decreasing the influx of leukocytes into the local area. Corticosteroids indiscriminently enter cells and suppress pro-inflammatory factors and stimulate anti-inflammatory mediators. This leads to non-selectivity and a variety of serious adverse effects.
Corticosteroids inhibit all inflammatory activity
Extra info: Although potent anti-inflammatory agents, they are unable to inhbit all inflammatory activity (e.g. mast cell degranulation, etc).
All actions of corticosteroids are evoked by binding to the corticosteroid receptor.
Extra info: The cellular effects of the corticosteroids are mediated by the corticosteroid receptor, but the local effects such as inhibition of arachidonic acid and leukotriene chemotaxis are not.