Nitroimidazoles are probably converted in an anaerobic environment into metabolites without a nitro group, which is toxic for protozoa (a prodrug). The mechanism of action of nitroimidazoles is inhibition of DNA synthesis and degradation of existing DNA.Metronidazole font-family: Verdana, Arial; font-size: medium; background-color: #e4eaff;"> and tinidazole are effective in treatment of amebiasis, giardiasis and trichomoniasis. Metronidazole is also a major anaerobe antibacterial drug.
Side effects of metronidazole include headache, nausea, dry mouth and metallic taste.
Pregnant and lactating women should NOT use nitroimidazoles.
Extra info: The effects of nitroimidazoles on pregnancy and lactation are unknown, but embryotoxicity has been shown in animal trials