Corticotropin-releasing hormone (CRH) released by the hypothalamus stimulates the pituitary corticotropic cells to secrete ACTH (adenocorticotrope hormone). ACTH stimulates the adrenal cortex,
I. ACTH stimulates adrenaline secretion from the adrenal gland. II. Chronic stress affects ACTH levels.
Extra info: ACTH stimulates only the cortex of the adrenal gland, especially the production of cortisol. Chronic stress affects the hypothalamus-pituitary-adrenal system: usually ACTH and cortisol levels are elevated.
The adrenal medulla produces the hormones