Monoclonal antibodies against the tumor cell are a relatively new and form of tumor destruction. Trastuzumab (Herceptin®) is a monoclonal antibody directed against the human
Trastuzumab is not very toxic for humans: it can cause cardiomyopathy in 2-3% of the patients. It is regarded as advance and metastatic breast cancer and metastatc stomach cancer, both when HER-2 positive.
I Monoclonal antibodies can be harmful to the patient. II HER-2 is a tyrosine kinase receptor.
Extra info: When an antibody recognizes a body own protein, the killer cells and macrophages can destroy the cells that produce the protein. HER-2 belongs to the group of tyrosine kinase receptors, which includes many growth factor receptors.