Daptomycin, being a cyclic lipopeptide, it belongs to a new class of antibiotics. It acts by formation of a pore in the bacterial membrane (1), causing leakage of potassium (2) and subsequent depolarization (3). This results in an arrest of bacterial cell function (DNA, RNA and protein synthesis; 4) and finally cell death (5).
Daptomycin has a bactericidal action on Gram-positive bacteria and is now registered for treatment of complicated skin and soft tissue infections caused by Gram-positive microorganisms in adults. There is limited experience with
The most important adverse effects include gastrointestinal complaints, skin reactions at the infusion site and increased serum creatinefosfokinase.
EPAR of daptomycin.