Proton pump inhibitors
Proton pump inhibitors for reflux
Acid inhibitory therapy is effective in healing reflux-oesophagitis and treating symptoms of reflux disease. With the powerful acid inhibition induced by PPIs (seeproton pump inhibitors for ulcers), over 95% of patients with reflux disease are cured after 12 weeks therapy. However, within one year after stopping therapy, over 75% of patients
Which effect is NOT related to PPI therapy?
Extra info: Due to lower gastric acid and increased pH after PPI therapy, there is an increase in gastrin secretion (as part of a feedback loop) and an increase in local bacteria. The PPIs are also potent inhibitors on the cP450 system.
Maintenance therapy with PPIs should be considered in patients with
Extra info: The severity of all three of the diseases warrants maintenance therapy with a PPI.