Antiepileptic drugs

Antiepileptics

The treatment of epilepsy is aimed at restoring the inhibitory functions in the brain and suppressing seizure activity. Three major mechanisms of drug action are used:

  • Potentiating GABA to enhance the inhibitory control and modulate the abnormal firing by:
    • Activating GABA-receptors (benzodiazepines and barbiturates; yellow drugs)
    • Inhibiting GABA reuptake (tiagabine; black drugs)
    • Inhibiting GABA breakdown (vigabatrin, valproic acid; not shown)
1

When considering stopping antiepileptic drugs the patient should

2

A patient is brought to the emergency room in status epilepticus. Which of the following is NOT indicated in the management of his condition?