Thiazolidinediones are a new group of drugs that improve insulin sensitivity. The precise mechanism of action is not known. Thiazolidinediones bind to peroxisome proliferator-activated receptors in the nucleus (PPARs), specifically PPARγ. In that way, thiazolidinediones alter transcription of certain genes.

They are most effective in adipose tissue, muscle tissue and the liver. Pioglitazon belongs to this group of drugs. When metformin or sulphonylderivatives are not effective, addition of thiazolidinediones to these drugs might obtain better effectivity.


I. Thiazolidinediones modulate gene expression.

II. Thiazolidinediones can be used during pregnancy.


Thiazolidinediones are useful for the treatment of