Saquinavir, ritonavir and indinavir are well-known protease inhibitors
All protease inhibitors cause gastrointestinal side effects. Moreover, long-term therapy can be implicated in lipodystrophy and dyslipidemia. All protease inhibitors are inhibitors of the CYP3A4 system and thus interact with numerous other drugs.
Saquinavir inhibits HIV replication by blocking uncoating of the virus during penetration.
Extra info: Saquinavir inhibits the splitting of viral proteins prior to assembly.
Combination of protease inhibitors and NRTI drugs produces additive antiviral effects and reduces the incidence of resistance.
Extra info: Due to this prevention of resistance, it is recommended to utilize combination therapy.
Indinavir is an irreversible inhibitor of the HIV protease.
Extra info: Indinavir is a reversible protease inhibitor.