Rational drug design plays an important role in the development of new anticancer drugs. Target therapy is such a new antitumor treatment.
Imatinib (Glivec®) is an inhibitor of the protein-tyrosine kinase. This enzyme plays a major role in the
I Imatinib interferes in the signal transduction. II Imatinib treatment is relatively safe for the patient.
Extra info: The tyrosine kinase enzyme that is inhibited by imatinib, is a part of the signal transduction. Treatment with imatinib is only available for chronic myeloid leukemia patients with stemcell transplants. However, high morbidity and mortality occurs during the treatment. In this case α-interferon is the preferred treatment.