Pharmacokinetic drug interactions
Interactions changing the kinetics of drug can be clinically very relevant. Metabolic interactions occur the most and can cause prolonged presence of drugs in the body.
The four most important levels of interactions are listed below:
See the website from the IUPUI for tables on CYP P450 interactions.
During what process would the concomitant use of lithium and furosemide likely interact?
Extra info: Lithium needs to be excreted through renal elimination. When given with furosemide (a diuretic), the lithium levels will increase due to the body’s attempt to conserve sodium and lithium ions.