The projections from the raphe nuclei to the locus coeruleus are inhibitory, thus decrease the effects of NE
Extra info: When benzodiazepine bind with the post-synaptic GABA-A receptor, the membrane threshold is relatively increased.
Benzodiazepines require the presence of GABA to be effective.
Extra info: Without GABA, the effect of benzodiazepines would be undeterminable.
Of the many benzodiazepines available on the market, they all have the same general pharmacological mechanism of action, but differ in terms of pharmacokinetic profile.
Extra info: This statement appears to be true at this time, as no true variation in pharmacological effect can be seen between the benzodiazepines.
Aside for use in anxiety disorders, benzodiazepines are also used for anesthesia, insomnia, and status epilepticus.
Extra info: The decrease in the membrane potential renders these agents useful for disorders where a decrease in neuronal stimulation is desired.