Mirtazepine blockade of pre-synaptic α2 receptors is unique amongst antidepressants.
Extra info: The MAOI's increase neurotransmission in all the neurons in which they are present.
Extra info: Taking this tyramine rich foods with a MAOI will lead to a hypertensive crisis, not the symptoms of a serotonin syndrome.
Hypertensive crisis may be the result of large amounts of norepinephrine being released into the synapse after large amounts of tyramine are ingested.
Extra info: This is the proposed mechanism for a hypertensive crisis.