GH (somatotropin) acts on different cell types in the body. In general, GH has great anabolic action on body cells. This means that GH stimulates RNA synthesis and protein synthesis. On bone tissue GH has growth promoting activities; most organs undergo increase in size and function upon GH stimulation. Most actions of GH are indirect and require insulin-like growth factor-1 (IGF-1), which is synthesised and secreted after GH stimulation by the liver.
Somatotropin is produced via DNA-recombinant techniques. The dosage depends on the age of the patient with GH disorders: in children the dosage is 2-4 times higher than in adults. Because growth hormone is a protein that would be degraded in the gut it is given by daily subcutaneous injections.
I. Acromegaly is associated with increased IGF-1 levels.
II. Frequent check of the adrenal function is recommended in patients receiving growth hormone therapy.
Extra info: Growth hormone overproduction results in increased IGF-1 levels that are produced by the target organ, the liver.