last updated 24-06-2024

Systemic lupus erythematosus

Immunology of SLE

The following model has been proposed for SLE:

  1. Antigen-presenting cells (APCs) take up necrotic cells and their antigens.
  2. In an inflammatory microenvironment auto-antigens are processed by APCs and presented to autoreactive Tcells.
  3. Autoreactive B cells take up autoantigen and arestimulated to proliferate by autoreactive primed T cells.
  4. Plasma cells derived from stimulatedautoreactive T cells secrete auto-antibodies, which cause inflammatory disease.

Which of the following biological molecules is never tested positive in SLE?