Drug regimen determination

If a drug company knows the average volume of distribution, clearance and the desired therapeutic range of a particular drug in a particular patient population, it is possible to determine an empiric dosage regimen. The suggested dosages in any therapeutic book are based on this process. Sometimes our patients don’t respond like the average patient and therefore the clinician should be able to determine an appropriate drug regimen for the patient. The concepts involved in giving a single intravenous dose (versus oral), and an intravenous infusion (versus multiple oral doses) will be demonstrated in the next few topics.


Also check here for changing dose in case of altered clearance.

Check here to find out the effects of changes in Vd, half-life and/or clearance on plasma concentration.