Ivabradine

Ivabradine

Ivabradine lowers the heart rate by inhibiting the cardiac pacemaker current that is responsible for diastolic depolarization.

Ivabradine acts on the sinus node as follows:

The most important side effect is the appearance of light flashes (phosphenes). The agent can be used in patients with angina pectoris when ß-blockers are insufficiently effective or not tolerated by the patient, provided that the heart rate is at least 60 bpm at the beginning of treatment.

EPAR of ivabradine