In cancer cells, the growth is out of control. It begins with a mutation in a portion of DNA, which leads to the production of abnormal proteins. A mutation in genes involved in cell growth (proto-oncogenes), differentiation or mitosis, can result in uncontrolled growth. The proto-oncogene becomes an oncogene (1). These abnormal proteins can behave as growth stimulating factor or cell division
What is NOT true?
Extra info: Close Proto-oncogenes regulate normal cell division. When these genes are mutated, they can disregulate cell division.
Compared with benign tumours, neoplastic tumours do NOT show:
Extra info: Uniform cell mass is a feature of benign tumour
What is true about a tumor suppressor gene?
Extra info: Tumor suppressor genes appear in all cells, are not controlled by oncogenes and certainly do not code for proteins which stimulate cell division.