Rational drug design

Rational drug design

Development of new antitumor drugs is one of the main items in cancer research. Molecular biology helps to understand more of tumor cells and creates new possibilities for rational drug design. The main problem still is that a tumor cell is not really distinguishable from a normal cell, except for the fact, that an abnormal protein is produced and that the cell grows and divides rapidly. And indeed those aspects are important for drug development. In the graphic various theoretically possible sites of intervention in the tumor cell cycle are shown:

In general, the concept for rational drug intervention requires high specificity for the tumor cell.