Non-steroidal anti-inflammatory drugs (NSAIDs)
Most drugs of the group of non-steroidal anti-inflammatory drugs (NSAIDs), or prostaglandin synthesis inhibitors are non-specific COX inhibitors. These drugs inhibit both isoforms of the cyclo-oxygenase enzyme: COX-1 and COX-2. They inhibit thus the conversion of arachidonic acid into prostaglandins. These drugs are used to inhibit pain stimuli (decrease pain intensity) and to lower inflammatory reactions and fever.
The non-specific nature of these drugs is responsible for most of the side effects. Because conventional NSAIDs also inhibit COX-1, general homeostatic functions like protection of the gastrointestinal tract, renal perfusion and platelet function are disturbed. Consequently, peptic ulcus can develop and/or kidney function can diminish. Since both, COX-1 and COX-2 influence platelet function in opposite way, the use of non-specific COX inhibitors usually does not result in side effects such as arterial thrombosis etc.
Which of the following is NOT an NSAID?
NSAIDs have the following effects in RA, EXCEPT
Extra info: NSAIDs are analgesic, anti-inflammatory and anti-pyretic, but do not decrease erosions.