TRC: H2-antagonists for reflux

H2 antagonists

H2-antagonists for reflux

H2-antagonists were originally introduced for the treatment of peptic ulcers (see H2-antagonists for ulcers). However, due to the high relapse rate of reflux patients taking antacids, maintenance therapy with H2-receptor antagonists (or PPI's) is often indicated.

Tolerance can occur and patients chronically using the H2-antagonists may require higher dosages than normal.

Famotidine and ranitidine act as anti-ulcer drugs because of antagonism at the parietal cell of

Extra info: Famotidine and rantidine lower gastric pH as they are specific for the H2 receptor.

Option explanation:

muscarinic M3 receptors

gastrin receptors

histamine H2 receptors

histamine H1 receptors

H2 antagonists

H2-antagonists for reflux

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