The negative symptoms of schizophrenia include symptoms such as anhedonia, bizarre behavior, and delusions.
Extra info: Although anhedonia is a negative symptom, bizarre behaviour and delusions are positive symptoms.
By using an antipsychotic to block post-synaptic D2 receptors, negative symptoms are reduced.
Extra info: Unfortunately, clinical experience shows us that giving a typical antipsychotic leads to worsening of the negative symptoms of schizophrenia.
5-HT2A receptor antagonism leads to a minimization of negative symptoms.
Extra info: Fortunately, by taking advantage of the differences in neuroanatomy with regard to 5HT2C receptors, we are able to minimize the effects of antipsychotics on negative symptoms.