Mast cell stabilisers
Antihistamines block the effects of histamine already released into the system. Another means of blocking the effects of histamine is by preventing its release from inflammatory cells. Nedocromil and cromoglycate
are substances that are thought to work by preventing degranulation of mast cells. These agents are only available by inhalation and are indicated for the prophylaxis of mild asthma. Unfortunately, poor clinical results with these agents limit their utility.
Mast cell stabilizers block the Ca++ mediated release of storage vesicles.
Extra info: Mast cell stabilizers inhibit the influx of Ca2+ into the cell, thus preventing exocytosis of the vesicles.
Nedocromil prevents the IgE/antigen complex from binding to the mast cell.
Extra info: Nedocromil is primarily involved with the entrance of Ca2+ into the mast cell and does not seem to interfere with the antigen presentation to the cell.