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    Alzheimer's disease

    Alzheimer's disease is the most common dementing disorder. The pathophysiology remains unknown, although several features are associated with its presence. These include genetic factors, excessive NMDA stimulation, a reduction in choline acetyltransferase activity, the presence of amyloid-beta plaques, and neurofibrillary tangles and neuroinflammation.

     

    These changes seem to start in the nucleus basalis of Meynert and progress through the cortex. This leads to a progressive, irreversible, neurodegenerative illness with cognitive loss, behavioural changes and a loss in independence being the major clinical symptoms. Treatment of Alzheimer's disease.

    1

    In Alzheimer’s disease, it is in the interest of the patient to ________ the effects of acetylcholine.

    2

    In Alzheimer’s disease, it is in the interest of the patient to __________ the glutamate activity at the NMDA receptor. 

    3

    Which of the following is NOT a criteria for dementia? 

    4

    Rivastigmine is an acetylcholine-esterase inhibitor and is used for the treatment of dementia. What is the primary effect of rivastigmine on the cholinergic transmission?