Antimycotics

Antimycotics

(and other drugs for vaginal infections)The treatment of fluor vaginalis depends on the microorganism causing the infection.

Candida infections are treated with the antimycoticsclotrimazole or miconazole applied as vaginal tablet or cream.

The azoles inhibit fungal ergosterol synthesis by inhibiting the conversion from lanogestrol by the enzyme P450 dependent lanosine 14α-demethylase. Since ergosterol is an essential compound of the membrane, its absence changes fluidity and action of membrane associated proteins.

As a consequence the fungal cell replication is inhibited.

Bacterial vaginosis is usually treated with metronidazole. This nitroimidazole is effective against Trichomonas vaginalis and Gardnerella species. The mechanism of action of nitroimidazoles is inhibition of DNA synthesis and degradation of existing DNA of the microorganism.

Chlamydia trachomatis infections are treated with azitromycin, a macrolide. Macrolides belong to the group of bacteriostatic antibiotics which inhibit bacterial protein synthesis.

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A common side effect of the azoles is: