Somatostatin is powerful inhibitor of GH secretion and in a lesser extent TSH secretion. Somatostatin acts via a G-protein coupled receptor. Octreotide and

href="">lanreotide are synthetic analogues of somatostatin.

Octreotide utilised in case of acromegaly is given intramuscular in depot injections once every 4 weeks (10-30 μg/ 4 weeks).


Octreotide can be used to treat acromegaly and various endocrine tumors in the GI tract.