Amantadine

Amantadine

Amantadine and its analogue rimantadine are primary amines with a large carbon ring. Their exact mechanism of action as antiviral drug is unknown. Amantadine inhibits an early step in viral replication: penetration of the virus into the host cell. It also

prevents the uncoating of the virus, thereby inhibiting the release of viral genetic material. Secondly, amantadine might also interfere with the last step in the replication cycle, thereby inhibiting viral assembly.

Amantadine is well absorbed orally and has a large volume of distribution. The drug is excreted largely unchanged in urine. Common side effects include gastrointestinal problems and CNS complaints. High doses can be neurotoxic and result in seizures or coma.

1

Amantidine is effective as therapy and prophylaxis against influenza A and B strains. 

2

Amantidine has relevant pharmacotherapeutic effects in Parkinson's disease.