Glucocorticoids in the immune response

Glucocorticoids in the immune response

Glucocorticoids (GCs) interfere at many sites in the activation and development of effective lymphocytes. They already inhibit the interaction between the APC and the CD4+ or CD8+ T-cell. Furthermore glucocorticoids inhibit the production of all kinds of cytokines (e.g. IL-2, IL-4). The overall result is an inhibition

of the effector cells: B cells, cytotoxic T cells and decreased activation of macrophages.For more information on glucocorticoid therapy in immunological diseases you are referred to the immunology chapter.Glucocorticoids in:allergic rhinitisdermatitisSLEtransplantationasthma