Ketoconazole inhibits two enzymes in the glucocorticoid synthesis. It blocks the cholesterol side chain cleavage enzyme, which converts cholesterol into pregnenolone and it inhibits the 11β-hydroxylase enzyme (like metyrapone). The final effect of ketoconazole is a decreased glucocorticoid synthesis. This drug can be used to control adrenal hyperfunction, caused by Cushing's syndrome or Cushing's disease.
Remember the role of ketoconazole in infectious diseases.
Ketoconazole does NOT have side effects.
Extra info: The main side effects of ketoconazole are: GI problems and liver disorders.