Metyrapone

Metyrapone

Metyrapone is a specific inhibitor of the enzyme 11β-hydroxylase, which is responsible for the conversion of 11-deoxycortisol into cortisol in the adrenal gland. Prior to surgery, metyrapone can be applied as an inhibitor of cortisol synthesis in the treatment of Cushing's disease or of Cushing's syndrome.

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The ultimate cure of Cushing’s disease is by surgery.