Histamineplays a major role in the response to allergen exposure. After being released bycells such as the mast cell seen in the previous topic, histamine can bind to several receptors.
So far 3 receptors have been identified as shown. Although its action is unclear, the H3 receptor appears to act as a negative feedback receptor.
All histamine receptors activate the same 2nd messenger systems.
H1, H2 and H3 receptors are located in each others proximity.
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