TRC: Leukotriene modifiers

Leukotriene modifiers

There are two types of agents that modify leukotriene response: inhibitors of LT synthesis that block lipo-oxygenase, and LTreceptor antagonists. The drugs zafirlukast and

target="_blank">montelukast belong to the latter group and are used more clinically. Zileuton is an inhibitor of leukotriene synthesis
In theory, these LTmodifying agents could have a major role in the treatment of asthma. Howevertheory and practice are not identical; many asthmatics appear not to have anybenefit from LT modifiers, which now are prescribed mainly for mild asthma orasthma with profound exercise-induced symptoms.

A leukotriene modifier has a combination of effects on both synthesis and leukotriene receptors.

Extra info: There are two different mechanisms for the leukotriene modifiers, they either inhibit the synthesis of the leukotrienes (zileuton) OR block the leukotriene receptor (zafirlukast). They can not do both.

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Leukotriene modifiers are treatment of first choice in asthma.

Extra info: Although the mechanism of action of these drugs seems promising, the clinical effectiveness has not been overwhelming.

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Leukotriene modifiers are NOT used for the treatment of COPD.

Extra info: Other drugs such as anticholinergics, β-agonists and steroids have a more profound effect on the relaxation of smooth muscle and are thus used in COPD.

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Leukotriene modifiers

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