Cyclophosphamide in transplant
Cyclophosphamide is a cyclic phosphamide ester of mechlorethamine. It is transformed via hepatic and intracellular enzymes to active alkylating metabolites, acrolein and phosphoramide mustard.
Cyclophosphamide causes prevention of cell division primarily by cross-linking DNA strands. It is considered to be cell
“Immune system modulation in the highly sensitized transplant candidate”; Davidson BT, Donaldson TA: Crit Care Nurs Q. 2004 Jan-Mar;27(1):1-9.
Which of the following are alkylating agents?