Alzheimer's disease is the most common dementing disorder. The pathophysiology remains unknown, although several features are associated with its presence. These include genetic factors, excessive NMDA stimulation, a reduction in choline acetyltransferase activity, the presence of amyloid-beta plaques, and neurofibrillary tangles and neuroinflammation. These changes seem to start in the nucleus basalis of Meynert and progress through
In Alzheimer’s disease, it is in the interest of the patient to ________ the effects of acetylcholine.
Extra info: Since there is a reduction in the production and neurotransmission of acetylcholine, therapy can be aimed at increasing the effects of acetylcholine.
In Alzheimer’s disease, it is in the interest of the patient to __________ the glutamate activity at the NMDA receptor.
Extra info: It is the chronic and excessive stimulation of the NMDA receptor by glutamate that leads to some of the pathological changes seen in Alzheimer's disease.
Which of the following is NOT a criteria for dementia?
Extra info: If the disturbance develops over a short period of time, it is wiser to consider delirium since dementias are a progressive disease and present themselves over a long period of time. It is also important to remember that the criteria require some evidence of a loss in functioning.